BDBM10404 (1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetracyclo[8.6.1.0^{1,12}.0^{6,17}]heptadeca-6,8,10(17),15-tetraen-14-ol::CHEMBL659::GALANTAMINE HYDROBROMIDE::Galantamin::Galanthamine::Galanthamine, 12::Lycoremine::Nivalin::Nivaline::Razadyne::Reminyl::US11643395, Compound 10::US9586925, Galantamine::galantamine
SMILES COc1ccc2CN(C)CC[C@@]34C=C[C@H](O)C[C@@H]3Oc1c24
InChI Key InChIKey=ASUTZQLVASHGKV-JDFRZJQESA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 101 hits for monomerid = 10404
Affinity DataKi: 62nMAssay Description:Inhibition of human AChE assessed as acetylthiocholine hydrolysisMore data for this Ligand-Target Pair
Affinity DataKi: 62nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine as substrateMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Tetronarce californica (Pacific electric ray) (Tor...)
University of Karachi
University of Karachi
Affinity DataKi: 190nM ΔG°: -9.32kcal/moleT: 2°CAssay Description:AChE and BChE inhibitory activities were measured in vitro by a modified spectrophotometric method. all the inhibition studies were performed using ...More data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibition of acetylcholinesterase (unknown origin) assessed as AChI hydrolysis using AChI and DTNB as substrate by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataKi: 300nMAssay Description:Inhibition of AChE by Ellman's assayMore data for this Ligand-Target Pair
Affinity DataKi: 500nMAssay Description:Binding affinity to AChE (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 540nMAssay Description:Binding affinity to AChE (unknown origin) assessed as inhibition constant incubated for 30 mins by ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 800nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Tetronarce californica (Pacific electric ray) (Tor...)
University of Karachi
University of Karachi
Affinity DataIC50: 418nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at ...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Tetronarce californica (Pacific electric ray) (Tor...)
University of Karachi
University of Karachi
Affinity DataIC50: 360nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at ...More data for this Ligand-Target Pair
Affinity DataIC50: 800nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.60E+3nMpH: 8.0 T: 2°CAssay Description:Test compounds were prepared in DMSO (maximum concentration used 1% v/v), and 10 μL of each (0.001-25 μm final concentration range) was inc...More data for this Ligand-Target Pair
Affinity DataEC50: 1.10E+3nMAssay Description:In vitro reversal of vecuronium-induced neuromuscular block in guinea pig hemi-diaphragm.More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Centre De Recherche Pierre Fabre
Curated by ChEMBL
Centre De Recherche Pierre Fabre
Curated by ChEMBL
Affinity DataIC50: 538nMAssay Description:In vitro inhibitory effect on rat AcetylcholinesteraseMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Centre De Recherche Pierre Fabre
Curated by ChEMBL
Centre De Recherche Pierre Fabre
Curated by ChEMBL
Affinity DataIC50: 750nMAssay Description:Inhibition against acetylcholinesterase (AChE)More data for this Ligand-Target Pair
Affinity DataIC50: 550nMAssay Description:Inhibition of human AChE by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of AChE (unknown origin) by Ellman colorimetric methodMore data for this Ligand-Target Pair
Affinity DataIC50: 980nMAssay Description:Inhibition of AChE (unknown origin) by microplate assayMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Tetronarce californica (Pacific electric ray) (Tor...)
University of Karachi
University of Karachi
Affinity DataIC50: 360nMAssay Description:Inhibitory activity of the compound against acetylcholinesterase (AChE) from Torpedo californica (Reversible type of inhibition)More data for this Ligand-Target Pair
Affinity DataIC50: 700nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide substrate incubated for 15 mins by spectrophotometry based Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2.08E+3nMAssay Description:Inhibition of ICR mouse brain AChE using acetylthiocholine iodide as substrate preincubated for 10 mins before substrate addition by modified Ellman'...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of AChE (unknown origin) assessed as reduction in acetylthiocholine iodide hydrolysis after 15 mins by Ellman methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2.67E+3nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of AChE by microplate assayMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Tetronarce californica (Pacific electric ray) (Tor...)
University of Karachi
University of Karachi
Affinity DataIC50: 9.00E+4nMAssay Description:Inhibition of human acetylcholinesterase using ATCI/DTNB as substrate preincubated for 30 mins followed by substrate addition measured for 60 mins by...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Tetronarce californica (Pacific electric ray) (Tor...)
University of Karachi
University of Karachi
Affinity DataIC50: 1.07E+3nMAssay Description:Inhibition of Torpedo californica AChE using ATCI substrate incubated for 30 mins by Ellman's method based spectrophotometryMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Tetronarce californica (Pacific electric ray) (Tor...)
University of Karachi
University of Karachi
Affinity DataIC50: 1.07E+3nMAssay Description:Inhibition of Torpedo californica AChE using ATCI substrate incubated for 30 mins by Ellman's method based spectrophotometryMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Centre De Recherche Pierre Fabre
Curated by ChEMBL
Centre De Recherche Pierre Fabre
Curated by ChEMBL
Affinity DataIC50: 1.17E+3nMAssay Description:Inhibition of AChE from rat cortex homogenate by Ellmans methodMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of acetylcholinesterase (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of AchE (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 350nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.01E+3nMAssay Description:Inhibition of human acetylcholine esterase preincubated for 10 mins followed by the addition of 550 uM of acetylcholine iodide as substrate measured ...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Centre De Recherche Pierre Fabre
Curated by ChEMBL
Centre De Recherche Pierre Fabre
Curated by ChEMBL
Affinity DataIC50: 1.03E+6nMAssay Description:Inhibitory activity against acetylcholinesterase (AChE) in rat brain homogenatesMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition AChE (unknown origin) using ATCI as substrate assessed as hydrolysis of ATCI after 10 mins measured every 1 min for 10 timesMore data for this Ligand-Target Pair
Affinity DataIC50: 7.39E+4nMAssay Description:Inhibition of AChE by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 530nMAssay Description:Inhibition of AChE by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 800nMAssay Description:Inhibition of human erythrocytes AChEMore data for this Ligand-Target Pair
Affinity DataIC50: 800nMAssay Description:Inhibition of human plasma AChEMore data for this Ligand-Target Pair
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of human erythrocytes BChEMore data for this Ligand-Target Pair
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of human plasma BChEMore data for this Ligand-Target Pair
Affinity DataIC50: 350nMAssay Description:Inhibition of AChE-induced amyloid beta aggregationMore data for this Ligand-Target Pair
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of human AChE incubated with compounf for 5 mins before addition of substrate acetylthiocholine iodide by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of human AChE by Ellman's assayMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibitory activity against acetylcholinesterase in human RBCMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Centre De Recherche Pierre Fabre
Curated by ChEMBL
Centre De Recherche Pierre Fabre
Curated by ChEMBL
Affinity DataIC50: 1.76E+3nMAssay Description:Inhibitory activity against acetylcholinesterase in rat brainMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Centre De Recherche Pierre Fabre
Curated by ChEMBL
Centre De Recherche Pierre Fabre
Curated by ChEMBL
Affinity DataIC50: 630nMAssay Description:Acetylcholinesterase inhibitory activity in rat striatal homogenatesMore data for this Ligand-Target Pair
Affinity DataIC50: 590nMAssay Description:Inhibition of AChE activityMore data for this Ligand-Target Pair
Affinity DataIC50: 800nMAssay Description:Inhibitory concentration against human erythrocyte AcetylcholinesteraseMore data for this Ligand-Target Pair